Its summer and lots of traffic through 1-10 tunnel and also the old Bankhead tunnel. I would go North on I-65 then South on I-165 to the alt90 exit. (exit 2 - New Bay Bridge Rd) Its about 6 mi of interstate. The route across that bridge is an industrial area and less traffic and all 4-lane back to I-10.
I have friends in North Mobile and they always use the bridge to avoid heavy traffic in Mobile.