To get to Reno, we always take the 89, 44, 36, 395 and 50 route. It is faster overall, keeps you out of the misery of the Central Valley and Sacramento and avoids the grade down from Echo pass, which I did not like pulling a 19' trailer. All of the roads are good with minor climbs. When you get off of the 395 in Carson, it is a little convoluted but clearly marked. Zephyr Cove is on the 50.