I almost always drive some distance at night especially on the way out. If I have to go up I5 I leave here at 3AM that gets me over the grape vine by about 6AM and beyond the LA traffic.
Night driving in areas with Elk populations is a little more adventurous we found on our way to Denver over the Christmas holiday. Those Elk are big and I think would do some hefty damage. Thankfully I was in my Jeep and was able to drive around it.
Anyway my DW doesn't like leaving in the middle of the night, but when it comes to driving through LA traffic, since she doesn't/won't drive I get my way.