When I'm traveling and simply make an overnight stop, I do not disconnect anything on my owe vehicle. Makes quick getaways easier. The real key is to know how your 7-pin cable is wired. If all have the is lights hooked up, there is minimal risk. However, if you have motorhome chassis power to your toad, you want to know where that power goes. Does it power a transmission lube pump, charge the toad battery or power a braking device? Do you want these things powered all night? I don't.
I have a standard Tekonsha Primus Brake Control from my Dodge pickup connected to a new Keystone 5th Wheel. No Motorhome, No Toad, No Jerry rigged equip.
If you are dry camping you might consider disconnecting. Some tow vehicles have a relay in line that controls the 12 volt to your towed trailer to turn it off when ignition is off. If you do not have this, then you have a direct connection to your tow vehicle battery and will be drawing current from it too. Thus if you have a lot of items on, you could weaken the tow battery and not be able to start when you are ready to leave.
Dr Quick has it right. Check the TV charge pin and make sure that there is not power with ignition off, if no power then OK to leave connected for overnight stops.
Caveat, I;ve heard of some brake controllers that also have power with igntion off, this could be a TV battery drain.