I would take the route that gets from So Cal to 95 North. Nice route and no stress of freeway driving.
The suggestion a poster made to take 101 North puts the OP so far off route it wouldn't be worth it.
2006 Chevy HD LBZ Duramax/Allison
2006 Holiday Rambler Savoy 30sks
The shortest route that Google gives crosses from Nevada into Oregon at OR 205, Fields-Denio, and then skirts Steens Mtn. (ie. Winnemucca to Burns). That's getting into some pretty remote country, though there shouldn't be any problems (apart from sparse gas stations).
It gives another option - US93 to Twin Falls, I84 NW to US395.
In terms of raw driving time, these alternatives differ only by a couple of hours (22-24hrs). Actual travel time will depend more on the number and length of stops.
O.K.- somebody clue me in- is the O.P. talking about starting at Los Angeles, California, or is there a Los Angeles in Nevada too????
and you will never run out of sage brush to count!
No that's starting from L.A.and following I-80 east to Winnemuca to 140 to 205. Love the Steens mtn area,BUT going up 205 is kinda lonely,but is one of my most favorite places in the country.You go thru Denio,almost no-one lives there and then thru Fields,absolutely awesome burgers and milkshakes. From there you have a choice of a gravel road up the east side of Steens Mtn and west side of the Alvord Desert to highway 78 Orrr,205 north and west of the Steens thru French Glen,nice RV park and several awesome restaurants for a population of 20 souls,thru the Malheur Wildlife Refuge north to Burns.From there would be 395 to Pendleton,84 west to 82 to Pasco-Richland and 395 to 90 and then over to Spokane.Now that's a real trip and nothing on it that the average person couldn't handle.