I have a Truxedo, around 6 years old. It still keeps the interior of the bed as dry as a truck bed can be - any water ingress is not from the top! It's a flexible cover, so not as secure as a hard cover, but it is extremely easy to roll up or down and latch, and there is no issue at all about using a FW with it - I've left it on when I carried my truck camper...
My buddy has this one on his Dodge 2500 SB. Seals well and can be folded back for the 5er. It also can be completely removed in a matter of minutes, if you wish. I plan on purchasing one for myself this year.
I have the hard panel folding top. It stayed water tight for five years then the rubber seal on the piano hinges started to crack and leak. I striped them off and replaced them with black duct tape, still looks good.
On the Fold-A-Cover it is a one person job. There are two locks, one on the front quarter and one on the rear quarter. When folded there are two straps that snap the four parts down. Honestly it is heavy enough I have not had a problem even when I forget to put the straps in place. When closed it covers my fifth wheel hitch and generator. Also when closed and locked it locks my tail gate in place too.