Man I forgot to add about that fuel filter, thanks for catching that. I really didnt feel it was the plugs or wires, only becuase GM has used some really cheap fuel pumps for some reason. My nieghbors has gone out 3 times on his 1/2 ton with the V6. I was told by the mechanic that if had to replace the fuel pump to only use the excat brand that came out, such as delco or other GM brand. Kinda scary knowing that your replacing it with the same make of pump or name... but so far on my brothers 5.3 it has worked out.
Most likely a fuel pressure regulator. Some brands of fuel are really tough on the diaphragm in these. It usually only acts up on a warm engine and it acts like it's flooded. A fuel pump usually causes a hard start when it cold because the pressure bleeds off. Pushing the accelerator to the floor shuts off the fuel while cranking. If it was the fuel pump it would never start. Replacing the fuel filter is a good thing to do often because the more it impedes the fuel flow the harder the pump has to work, but in my 25 years in the auto service business, I never saw one keep an engine from starting. My bet is the regulator.
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IB my DD car would start just fine after it ran, just the first start it would crank almost twice as long. If it had a pin leak in the fuel system anywhere you would smell raw fuel.
When I pulled the plugs I was floored the thing was running at all. The center electrode was warn to a point, the new plugs were round and flat. The gap on the old plugs checked .065/.080 that's .020/.035 over the .045 +/-.005 the factory specs for them.
OH BTW if you change the plugs and wires go with AC Delco or you will be doing it over again....don't ask!!! I think it's a GM thing
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With a Vortec he should not have to hit the peddle to start it. So something else is the issue. Be it electrical ala plugs wires etc. Which 454's were known to go through, or a fuel issue, be it a pump, regulator, filter etc. With 100K miles, that is the first tuneup schedule for that motor, so it is possible it has never had a tuneup!
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Marty is correct pushing down on the throttle will not add fuel to the engine. The injectors will spray when the ignition key is turned to the start position only. That is why if your vehicle does not start you turn the key off then back on to respray, but if you keep doing this you will flood the engine just like an older carb vehicle.
I'm not saying there is not a fuel pump/regulator issue but again 100K is the first scheduled tune up for modern engines. That is a long time for a set of plugs and wires to go.