Since you are in the minivan, depends on what you want. To just get there, and see some scenery, take route 12.
If you want to see lots of the countryside you could take the very scenic route -- follow I81 to NY 26 N into Rome then take NY 46 N to Boonville where you turn right in the middle of town the right onto NY 12 S for a very short distance then a left onto Moose River Road which brings you back onto NY 28 where you take a left over the river. Both the Boonville gorge on rt 46 and the Moose River Road were two of my favorite rides when I lived in that area.
2008 Keystone Laredo 265RL
2008 Silverado 2500HD CC, LB, 2x4, DuraMax 6.6/Allison
ICOM 706 MK II G