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 > Your search for posts made by 'dturm' found 186 matches.

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RE: A very old stray {The Old Fella Story}

I'm not surprised by the Moderna producing more antibodies as their shot had 100 micrograms dose while the Pfizer had 30 microgram. This is probably why they are going to recommend a 3rd shot the end of this month. Stay safe on your travels, and have fun.
dturm 09/01/21 12:57pm RV Pet Stop
RE: 2019–2022 CORONAVIRUS PANDEMIC POSTINGS

Steve that's great. My wife had her third Pfizer 10 days ago. No plans for antibody testing at this point.
dturm 09/01/21 09:19am Around the Campfire
RE: 2019–2022 CORONAVIRUS PANDEMIC POSTINGS

Effective? There are protocols that are way more effective than early last year. I know many drugs and combinations are used along with supportive care depending on severity of the cases. The development of monoclonal antibodies given early in the course of the disease is reported to be helpful. Bottom line, there is no one treatment that guarantees a good outcome. As a rule in medicine, prevention is the best medicine.
dturm 08/31/21 05:51pm Around the Campfire
RE: A very old stray {The Old Fella Story}

Just read a preprint of a study out of Israel. Good news is that they found a 3rd booster provided big improvement in protection from Delta, many fewer infections in vaccinated individuals. They started giving 3rd boosters to people >60 in July. They postulate that this will aid greatly is stopping the Delta spread. Sandy got her 3rd Pfizer vx about 10 days ago (per her rheumatologist's recommendation). We too are masking and avoiding large gatherings.
dturm 08/30/21 01:58pm RV Pet Stop
RE: 2019–2022 CORONAVIRUS PANDEMIC POSTINGS

Politico report on recent cohort study CDC report Vaccinated still 80% protection from infection with vaccine.
dturm 08/30/21 10:37am Around the Campfire
RE: 2019–2022 CORONAVIRUS PANDEMIC POSTINGS

Jim, I understand your frustration but there are two major reasons why vaccination is still a good idea. 1. As Mark listed above, unvaccinated people are 17X more likely to end up in the hospital. In all probability the cases you and your family members had would have been more serious. 2. Many people vaccinated do not get re-infected. The more we can limit the number of times this virus reproduces through infection, the greater the chance we can limit mutations that cause problems, like the Delta variant. Your experiences are evidence why it's still important to take reasonable preventive measures.
dturm 08/30/21 09:44am Around the Campfire
RE: 2019–2022 CORONAVIRUS PANDEMIC POSTINGS

Definition of Vaccine from Wikipedia https://en.wikipedia.org/wiki/Vaccine A vaccine is a biological preparation that provides active acquired immunity to a particular infectious disease. A vaccine typically contains an agent that resembles a disease-causing microorganism and is often made from weakened or killed forms of the microbe, its toxins, or one of its surface proteins. The agent stimulates the body's immune system to recognize the agent as a threat, destroy it, and to further recognize and destroy any of the microorganisms associated with that agent that it may encounter in the future. Vaccines can be prophylactic (to prevent or ameliorate the effects of a future infection by a natural or "wild" pathogen), or therapeutic (to fight a disease that has already occurred, such as cancer). Some vaccines offer full sterlizing immunity, in which infection is prevented completely.
dturm 08/29/21 05:08am Around the Campfire
RE: 2019–2022 CORONAVIRUS PANDEMIC POSTINGS

Ivermectin has been in the news recently and real accurate information about this drug should be shared. Most people who follow this thread probably are not considering Ivermectin as a treatment but probably do have friends or family members who are. As a veterinarian, I have prescribed and used this drug more than any other since the mid 80s. Below is a information from the NIH and CDC. NIH CDC The most important take away is: Ivermectin has been shown to inhibit the replication of SARS-CoV-2 in cell cultures. However, pharmacokinetic and pharmacodynamic studies suggest that achieving the plasma concentrations necessary for the antiviral efficacy detected in vitro would require administration of doses up to 100-fold higher than those approved for use in humans. In the real world, we primarily use Ivermectin in my branch of veterinary medicine as a heartworm preventive dosed at 6-12 mcg /kg (that’s micrograms NOT milligrams) once a month. At this dosage level this drug is extremely safe for dogs and yet there are some (very, very few) minor reactions. It is also used at 10X (or more) dose more frequent dosage (daily) for some ectoparasite problems (mange). This drug becomes problematic for many individuals at this level and is contraindicated for those specifically with a ABCB1 (formerly MDR1) mutation found frequently in collie related breeds. THIS MUTATION IS ALSO FOUND IN PEOPLE. The most common serious reactions have to do with neurological issues leading to seizures in susceptible individuals. Similar adverse reactions have been reported in all species we treat, horses, cattle, sheep, rodents and birds, reptiles and probably others I’m not aware of. The major compounding issue using animal drugs is the dosage calculations. One has to convert the dose micrograms per kg to pounds, to milligrams, to the animal strength (1% in the cattle version) to the milliliter liquid dose. I do this calculation frequently and always double check and have someone check my work. People not familiar with these values and the math are prone to making mistakes, and with the concentrations of these medications MISTAKES ARE SERIOUS. Also of interest is the interaction of concurrent use of other medications with Ivermectin, specifically statins, warfarin, calcium channel blockers. Do a search about calls to poison control centers about ivermectin and you will get multiple hits from many states with recent astronomical increases in calls. Contrary to “news” talking heads and internet sites, this drug is not innocuous. It should only be used under the supervision of YOUR doctor that knows your history and concurrent medication history, and frankly until there is conclusive evidence that it actually safely works to prevent or treat COVID, there are better, safer and approved treatment and preventives. Doug DVM
dturm 08/28/21 07:23am Around the Campfire
RE: A very old stray {The Old Fella Story}

Glad that your wife is doing better. I know it seems like many people who got vaccinated are getting COVID and are reported in the press. The reporting skews things as we don't see the vaccinated people who were also exposed and NOT infected. The only way we get this information is through cohort studies. This is where all people (both vaccinated and unvaccinated) in a population are routinely tested. Stats can be developed to compare relative infection rates and protective effects of the vaccine. These are being done and stats still show amazing protection from the vaccines. Certainly not as effective with Delta as with the original wild strain and also with waning immunity as time from vaccination lengthen. The bottom line is that as long as this thing is being spread like it is now, we're all at risk. The only way to tamp this thing down is to vaccinate more people and continue to take public health measures to mitigate spread.
dturm 08/27/21 07:18pm RV Pet Stop
RE: A very old stray {The Old Fella Story}

Sorry to hear about your COVID adventures. Florida is a high community spread area right now. Were you guys vaccinated? Also, consider inquiring about monoclonal antibody treatment. Given early it can make a difference in severity and eventual outcome. Also, I think the monoclonal antibody treatment is free - treatment costs are picked up by one of the congressional acts.
dturm 08/27/21 12:27pm RV Pet Stop
RE: Goodbye old friend, You will be missed

Sorry for your loss. It seems you had many good years and experiences with her and you eased her final years and repaid some of the companionship and love she gave during her life.
dturm 08/27/21 04:56am RV Pet Stop
RE: Views on when to/not to allow a dog to be social

We never allow them to interact with other dogs. Although there is unlikely to be a problem, it is so unpredictable as to the aggressiveness of the other unknown animals or any health issues we just don’t take the chance. My position too. I've seen the results of meet and greets and dog parks too many times to risk taking a chance. Socialization can occur with other than random animals, your own dogs and neighbors where you know behavior and health status. Also, until your dog has completed his puppy series of shots, it's not a good idea to mix. Their version of social distancing.
dturm 08/26/21 12:56pm RV Pet Stop
RE: COVID PERSONAL EXPERIENCES

My other half has RA and is on immunosuppressants. She got her 3rd Pfizer vaccination yesterday (as recommended by her rheumatologist) and so far nothing other than a little sore arm.
dturm 08/21/21 07:36am Around the Campfire
RE: 2019–2022 CORONAVIRUS PANDEMIC POSTINGS

I see reports that they are still using the monoclonal antibodies as treatment, but I have not heard anyone speculate on the efficacy in Delta infections. The difficulty in determining breakthrough case incidence is that a huge majority are "probably" not reported, minor cases in vaccinated people where testing isn't even done. The stats compiled are from "cohort" studies where a population is regularly tested (both vaccinated and not) and positives are reported.
dturm 08/18/21 03:19pm Around the Campfire
RE: 2019–2022 CORONAVIRUS PANDEMIC POSTINGS

OK, to be technically correct the genetic sequencing from the wild type coronavirus was used as the template to create the mRNA that would stimulate production of the spike protein of that wild strain thus stimulating an immune response. My wife has RA and contacted her rheumatologist. She previously had an antibody test showing a response to the Pfizer vaccine, but he recommended a third shot and she's scheduled for Friday. We'll report on reactions.
dturm 08/17/21 03:29am Around the Campfire
RE: 2019–2022 CORONAVIRUS PANDEMIC POSTINGS

Part of the issue here is understanding what a vaccination is supposed to do. Ideally a vaccination should prevent infection 100% of the time. In reality most have much less efficacy AND some are designed and are effective in preventing disease not infection. We're running into two issues here. First, the wild coronavirus (the first variation) was what was used to produce the vaccine. The first vaccines are very effective in preventing infection AND disease with this variant. Second, the coronavirus has mutated and has multiple variants now (and will continue to mutate and produce additional variants). The vaccines are less effective against these variants due to both the mutations and possibly due to waning immunity in those vaccinated several months ago and due to the huge increase in virus particle production with the new variants. The good news is that these vaccines are still preventing serious disease (necessitating hospitalization). Had you not been vaccinated, I suspect all of you would have more serious disease. Sorry you are going through this. I guess your experience is a warning to the rest of us to continue to take this thing seriously. Dr. Doug PS - an early preprinted report indicates that the Moderna vaccine is more effective in preventing breakthrough infections, BUT it's not known when the cohort reporting was done and the relative prevalence of delta vs wild strains in the populations that were reporting. Therefore, these results still need more examination before we make serious conclusions.
dturm 08/16/21 07:10am Around the Campfire
RE: 2019–2022 CORONAVIRUS PANDEMIC POSTINGS

Living adjacent to Chicago, the Lollapalooza choice was a curious one. While they did require proof of vaccination or a negative corona test within 72 hours for admission and the wearing of masks in indoor spaces, it will be "interesting" to see what happens from an epidemiological standpoint. I think the decision to have the Sturgis rally equally or more problematic.
dturm 08/10/21 06:01am Around the Campfire
RE: Tully's heart murmur-good news!

Great news. This is a pretty common situation.
dturm 08/09/21 02:36pm RV Pet Stop
RE: 2019–2022 CORONAVIRUS PANDEMIC POSTINGS

The other issue is a public health philosophical issue. Will more people in this country be protected more rapidly from these variants and future variants if the vaccine supply is distributed around the world? The WHO thinks so, but some public health officials point to the fact that the US is a major hot spot right now and we need to shut this thing down now. While ignoring the rest of the world will come back to bite us, we need to concentrate on the US right now IMO. Pfizer and Moderna are reworking their vaccine to include the Delta spike protein to increase efficacy of their vaccines. Testing is supposed to start soon. Regarding breakthroughs, even if it happens the vaccine is still almost 100% effective in prevent serious illness and hospitalization. We hear about the breakthroughs, but in reality they are very rare. Hospitalizations and deaths right now are close to 100% non-vaccinated individuals. We need to get more people vaccinated so people like Steveh27 can breathe more easily. There are a lot of people in his situation.
dturm 08/06/21 10:21am Around the Campfire
RE: Peas in dog food associated with dilated cardiomyopathy

I don't see grain allergies more prevalent, I just think we're better at diagnosing them. And they really are NOT that common. It is way more common to have an allergy to the protein (meat) component. I don't see any benefit to grain free unless there is a documented allergy, and then I'd recommend a limited ingredient food avoiding that antigen. Regarding switching foods: allergies don't seem to be more common with greater volume of one food stuff being fed. The exposure to more antigens (many different foods) increases the chance that you will run across one that stimulates the allergic reaction. That being said, food allergies are relative uncommon in dogs and cats. I hope we're finding the cause of the cardiomyopathy associated with grain free foods. Until the causal relationship has been verified, I still recommend avoiding grain free foods. Doug, DVM
dturm 08/06/21 10:00am RV Pet Stop
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