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Open Roads Forum  >  Around the Campfire  >  General Topics

 > 2019–2022 CORONAVIRUS PANDEMIC POSTINGS

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JaxDad

Greater Toronto Area

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Posted: 08/19/21 06:22am Link  |  Quote  |  Print  |  Notify Moderator

pianotuna wrote:

MEXICOWANDERER wrote:

What was posted here should go in the 'Covid Personal Experience' thread. (Mod)


I can't find that thread.


---------------
Thread: Covid Personal Experiences (Mod)


Don, it is the ‘sticky’ thread directly above this one.

BCSnob

Middletown, MD

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Posted: 08/19/21 08:13am Link  |  Quote  |  Print  |  Notify Moderator

Here is a recently posted report (community observational study) from a study by Oxford U.

Impact of Delta on viral burden and vacc........inst new SARS-CoV-2 infections in the UK

2 doses of either Pfizer or AstraZeneca vaccines continue to provide protection against the delta variant relative to being unvaccinated. Relative to protection against the alpha variant, there was reduced protection against delta. The protection appeared to diminish with time from the second dose with the reduction being larger after the second dose of AstraZeneca than Pfizer. In breakthrough infections with either vaccine, the viral loads were similar to those in the unvaccinated.

  • Being vaccinated is safer than not
  • Delta is more likely to yield breakthrough infections than alpha
  • Breakthrough infections with delta have higher viral loads than breakthrough infections with alpha
  • Viral loads with delta are similar in the unvaccinated (more likely to be infected) and vaccinated (much less likely to be infected)


The news is reporting reductions in vaccine effectiveness. This statement could be interpreted as the vaccines were not worth it because they have a short duration of immunity. In reality, the vaccines have different effectiveness against each of the variants and the data being analyzed is for an every changing mix of variants causing infections. I know this is a subtle difference and is irrelevant in terms of our protection; however, this subtle difference can play into our trust in the current vaccines and new vaccines/boosters. The vaccines have been/are effective against the variant for which they were developed; the problem is SARS-CoV-2 is evolving/changing (not as fast as influenza) but faster than vaccine development & approval. Because of this ever changing mix of variants we may never be able to measure the duration of immunity of the vaccines against the original variant. Immunity (due to past infections or vaccination) guides the evolution of viruses to select for genetic changes that survive in the presence of antibodies/immunity. The key is to minimize the number of hosts where the virus can survive and evolve.

* This post was last edited 08/19/21 08:47am by BCSnob *   View edit history

cptqueeg

Idaho

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Posted: 08/19/21 04:00pm Link  |  Quote  |  Print  |  Notify Moderator

changing notifications only, no other msg

jetboater454

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Posted: 08/19/21 07:39pm Link  |  Quote  |  Print  |  Notify Moderator

Other half son got the delta after being totally vaxed. Has any study been done or ongoing as to if you can get the variant twice? All I have been able to find is the breakthrough cases.


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BCSnob

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Posted: 08/20/21 09:19am Link  |  Quote  |  Print  |  Notify Moderator

Here is another preprint looking at breakthrough infections with the alpha vs delta variants.

Infection with the SARS-CoV-2 Delta Vari........ Unvaccinated and Vaccinated Individuals

Quote:

Taken together, we hypothesize that the notable increase in the time since receiving the vaccines combined with increased fitness of the Delta variant predisposes both vaccinated and unvaccinated individuals to symptomatic SARS-CoV-2 infections that are associated with high viral loads and transmission. Non-pharmaceutical interventions that include universal masking and social distancing to diminish transmission might be warranted to help control the summer 2021 Delta surge in the US. Booster vaccinations in groups at high risk of severe COVID-19 should be investigated to help reduce the burden of COVID-19 on the medical infrastructure.


  • Delta is more infectious than alpha
  • Delta produced more breakthrough infections
  • Delta produced the same vial loads in unvaccinated and vaccinated infections
  • Delta came along later than alpha relative to when vaccination occurred
  • Less antibody was found in airways in delta breakthrough cases than in alpha breakthrough cases
  • Increased delta breakthroughs may be due to more fitness in delta than alpha and/or waning antibody levels


BCSnob

Middletown, MD

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Posted: 08/20/21 11:17am Link  |  Quote  |  Print  |  Notify Moderator

jetboater454 wrote:

Has any study been done or ongoing as to if you can get the variant twice? All I have been able to find is the breakthrough cases.
The term to look up is reinfection not breakthrough. Based upon these and other articles found, determining a true reinfection by the same variant from a relapse of the first infection is difficult.

Quote:

Recurrent COVID-19 including evidence of reinfection and enhanced severity in thirty Brazilian healthcare workers
Journal of Infection Volume 82, Issue 3, March 2021, Pages 399-406


This is the first detailed case series showing COVID-19 recurrence with qRT-PCR positivity. For one individual detection of phylogenetically distinct genomic sequences in the first and second episodes confirmed bona fide renfection, but in most cases the data do not formally distinguish between reinfection and re-emergence of a chronic infection reservoir. These episodes were significantly associated with reduced Ab response during initial disease and argue the need for ongoing vigilance without an assumption of protection after a first episode.


Quote:

COVID-19 reinfection in the presence of neutralizing antibodies
National Science Review, Volume 8, Issue 4, April 2021


In our study of 273 patients, we report six cases of reinfection that all had negative PCR test results between the positive PCR tests during the two infection periods. In five of the six patients, viral genome sequencing results show unambiguous infection of a distinct viral strain in the second episode that was not in wide circulation prior to the time of secondary infection, ruling out the possibility of a relapse from primary infection. Of note, reinfection could occur shortly after recovery from primary infection. In addition, some of these patients mounted immune responses within the range that would be considered protective based on prior studies, yet were reinfected. These findings have strong and important implications for public health policy decisions, as well as in guiding efficacy assessment and development of vaccines.


Reinfection, recurrence, or delayed presentation of COVID-19? Case series and review of the literature
Journal of Infection and Public Health Volume 14, Issue 4, April 2021, Pages 474-477

BCSnob

Middletown, MD

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Posted: 08/20/21 12:36pm Link  |  Quote  |  Print  |  Notify Moderator

New preprint
COVID-19 Incidence and Hospitalization Rates are Inversely Related to Vaccination Coverage Among the 112 Most Populous Counties in the United States
MedRxiv Preprint

Quote:

The median vaccination coverage across all 112 counties was 49.95 percent.


The counties with vaccination rates above 49.95% had an average vaccination rate of 57.37%; the lower half's average vaccination rate was 42.61%

The covid case rates (over 14 days ending Aug 12) were:
280.6 per 100,000 (for 57% vaccination rate)
543.8 per 100,000 (for 42% vaccination rate)

The covid hospitalization rates (over the same period) were:
20.48 per 100,000 (for 57% vaccination rate
55.37 per 100,000 (for 42% vaccination rate)

Higher case rates, higher hospitalization rates, and greater risk of covid case leading to hospitalization where the vaccination rates were lower. The differences in illness were large considering the average vaccination rates were 15 percentage points different.

I'm happy to be working in one of the counties in this study where we have one of the highest vaccination rates (72% as of 20Aug21) and lowest case rates (10.3/100,000 as of 20Aug21); AND we have reinstated mandatory indoor mask use in public spaces because our cases were rising.

pianotuna

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Posted: 08/22/21 04:04pm Link  |  Quote  |  Print  |  Notify Moderator

News about Lambda variant.

https://www.news-medical.net/news/202108........immune-response-via-spike-mutations.aspx


Regards, Don
My ride is a 28 foot Class C, 256 watts solar, soon to have SiO2 batteries, 3000 watt Magnum hybrid inverter, Sola Basic Autoformer, Microair Easy Start.

BCSnob

Middletown, MD

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Posted: 08/22/21 06:00pm Link  |  Quote  |  Print  |  Notify Moderator



First sentence of the abstract of the study

Quote:

This manuscript concisely reports an in-silico study on the potential impact of the Spike protein mutations on immuno-escape ability of SARS-CoV-2 lambda variant.

Cutting epitopes to survive: the case of lambda variant

I wasn’t sure people would be interested in the results of computer modeling studies. There are more preprints of computer modeling studies if anyone is interested.

FYI, when studies refer to monoclonal antibodies those are the treatments when talking about immune responses produced by a body those are polyclonal antibodies.

* This post was last edited 08/22/21 06:24pm by BCSnob *   View edit history

BCSnob

Middletown, MD

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Posted: 08/23/21 06:27am Link  |  Quote  |  Print  |  Notify Moderator

Here is some data that is hopeful.

Covidactnow.org

The positive test rates generally proceed what will happen to the case & hospitalization rates. The positive test rates for MS, LA, AL & and the country as a whole appear to have plateaued and in some cases peaked and are declining. The rise in positive test rates in FL have slowed but have not plateaued or peaked yet.

However, positive test rates are increasing in other states: TX, SC, TN, WA, OR, WV, SD

* This post was last edited 08/23/21 06:43am by BCSnob *   View edit history

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