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Open Roads Forum  >  Around the Campfire  >  General Topics

 > 2019–2022 CORONAVIRUS PANDEMIC POSTINGS

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dturm

Lake County, IN

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Posted: 09/15/21 07:08pm Link  |  Quote  |  Print  |  Notify Moderator

Hypertension is a mitigating factor in COVID and the Ace2 inhibitors are used to treat hypertension. I looked this up last year as I take Lisinopril and at that time it was thought that it may actually help. There are studies going on right now.

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MEXICOWANDERER

las peñas, michoacan, mexico

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Posted: 09/18/21 02:02pm Link  |  Quote  |  Print  |  Notify Moderator

Regarding prime + boost vaccinations would a second like mRNA booster be considered as overboosting? (A theoretical hypothesis)

pianotuna

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Posted: 09/18/21 03:50pm Link  |  Quote  |  Print  |  Notify Moderator

Mex CDC is recommending a 3rd dose for folks of 65. I guess that includes rather a lot of us.


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My ride is a 28 foot Class C, 256 watts solar, soon to have SiO2 batteries, 3000 watt Magnum hybrid inverter, Sola Basic Autoformer, Microair Easy Start.

MEXICOWANDERER

las peñas, michoacan, mexico

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Posted: 09/18/21 07:37pm Link  |  Quote  |  Print  |  Notify Moderator

Prime boosting has been analyzed by the NIH to yield 6x increase in B antigens. I am concerned about overstimulation of the immune system. i.e. a miniature cytokine event.

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Posted: 09/18/21 07:58pm Link  |  Quote  |  Print  |  Notify Moderator

Back to providing data please: "Prime boosting has been analyzed by the NIH to yield 6x increase in B antigens."

MEXICOWANDERER

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Posted: 09/18/21 10:40pm Link  |  Quote  |  Print  |  Notify Moderator

https://scholar.google.com.mx/scholar?q=........d-19&hl=en&as_sdt=0&as_vis=1&oi=scholart
MEXICOWANDERER wrote:

Prime boosting has been analyzed by the NIH to yield 6x increase in B antigens. I am concerned about overstimulation of the immune system. i.e. a miniature cytokine event.


MEXICOWANDERER

las peñas, michoacan, mexico

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Posted: 09/18/21 11:06pm Link  |  Quote  |  Print  |  Notify Moderator

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7365308/

et al...

BCSnob

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Posted: 09/20/21 06:46am Link  |  Quote  |  Print  |  Notify Moderator

Pfizer announced summary of early results from phase 3 vaccine trial on 5-11 year olds. Filing for EAU and submission for peer review publication to occur very soon.

Press Release

Quote:

Pfizer said it is expecting trial data for children as young as 6 months "as soon as the fourth quarter of this year."


* This post was edited 09/20/21 07:04am by BCSnob *

MEXICOWANDERER

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Posted: 09/20/21 11:05am Link  |  Quote  |  Print  |  Notify Moderator

To date have there been any other than incremental mutations with the COVID-19 spike protein? Every relevant virus seems to have a bell curve of mutations. With respect to this pandemic, billions are unvaccinated. Are significant mutations more common within the unvaccinated multiple infected? Or to put it another way, less common among the infected fully vaccinated?

BCSnob

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Posted: 09/20/21 11:29am Link  |  Quote  |  Print  |  Notify Moderator

Vaccine-escape and fast-growing mutations in the United Kingdom, the United States, Singapore, Spain, India, and other COVID-19-devastated countries
Genomics Volume 113, Issue 4, July 2021, Pages 2158-2170

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SARS-CoV-2 has more than 28,000 unique single mutations, with nearly 7000 of them on the S protein, which are intractable for experimental means.


Quote:

In May 2020, an intensively validated topology-based neural network tree (TopNetTree) model [21] was employed to predict certain RBD mutations, including E484K, L452R, and K417N, would strengthen SARS-CoV-2 infectivity [15]. These predictions have been confirmed [[17], [18], [19]]. Additionally, all 451 new RBD mutations occurred since May 2020 were predicted as the most likely mutations in our work published online last May [15].


Quote:

The objective of this work is to track the fast-growing RBD mutations in pandemic-devastated countries and to analyze its evolutionary tendency around the world based on one of the most comprehensive data sets involving 506,768 SARS-CoV-2 genome sequences shown in the Mutation Tracker (https://users.math.msu.edu/users/weig/SARS-CoV-2_Mutation_Tracker.html). We found 6945 unique single mutations on the S protein and among them, 1024 occurred on the RBD. In terms of protein sequence, 100 of 651 non-degenerate mutations on the RBD were observed more than 28 times in the database and are regarded as significant mutations. We show that in addition to mutations N501Y, E484K, and K417N in the UK, South Africa, and Brazil(ian) variants, L452R, E484Q in the India variants, N439K, S477N, S477R, and N501T are also fast-growing mutations in 31 pandemic-devastated countries in the past few months. Using the TopNetTree model [21,22], we discover that essentially all 100 most observed mutations on the RBD are associated with the BFE strengthening of the binding of the RBD and ACE2 complex, resulting in more infectious SARS-CoV-2 variants. Considering mutation occurrence probability and ability to disrupt antibodies, we identify vaccine-escape and vaccine-weakening RBD mutations. The present finding suggests that S protein RBD mutations, in general, make the virus more infectious and are disruptive to the existing vaccines and antibody drugs.


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