RV.Net Open Roads Forum: Around the Campfire: 2019–2022 CORONAVIRUS PANDEMIC POSTINGS

RV Blog

  |  

RV Sales

  |  

Campgrounds

  |  

RV Parks

  |  

RV Club

  |  

RV Buyers Guide

  |  

Roadside Assistance

  |  

Extended Service Plan

  |  

RV Travel Assistance

  |  

RV Credit Card

  |  

RV Loans

Open Roads Forum Already a member? Login here.   If not, Register Today!  |  Help

Newest  |  Active  |  Popular  |  RVing FAQ Forum Rules  |  Forum Posting Help and Support  |  Contact  

Search:   Advanced Search

Search only in Around the Campfire

Open Roads Forum  >  Around the Campfire  >  General Topics

 > 2019–2022 CORONAVIRUS PANDEMIC POSTINGS

Reply to Topic  |  Subscribe  |  Print Page  |  Post New Topic  | 
Page of 163  
Prev  |  Next
Sponsored By:
silversand

Montreal

Senior Member

Joined: 09/12/2004

View Profile



Posted: 11/27/21 10:38am Link  |  Quote  |  Print  |  Notify Moderator

BC Snob wrote:

My guess >12 months

Moderna has mRNA-1273.351 (beta variant) in phase 3 clinical trials now. The beta variant was sequenced in Oct 2020.


Was there any precedent in the past where a vaccine trial had proved "overwhelmingly successful" within, gulp, 60 days, and EUA issued?

I wonder (really, am curious) if Moderna's 1st strategy (in the linked press release, above) will reveal anything positive over next few months (in recipients of the 100µg dose of mRNA-1273) against omicron.


Silver
2004 Chevy Silverado 2500HD 4x4 6.0L Ext/LB Tow Package 4L80E Michelin AT2s| Outfitter Caribou

BCSnob

Middletown, MD

Senior Member

Joined: 02/23/2002

View Profile



Posted: 11/27/21 10:48am Link  |  Quote  |  Print  |  Notify Moderator

The short answer is no

Preclinical trials (safety & efficacy)
need to be performed on animals before human clinic trials can be conducted. Plus the manufacturing of the new vaccine needs to be worked out and doses stock piled.

* This post was last edited 11/27/21 11:55am by BCSnob *   View edit history

BCSnob

Middletown, MD

Senior Member

Joined: 02/23/2002

View Profile



Posted: 11/28/21 04:21am Link  |  Quote  |  Print  |  Notify Moderator

Pfizer/BioNTech just addressed the timeframe to manufacture their mRNA vaccine targeting a new variant.

Quote:

“Pfizer and BioNTech have taken actions months ago to be able to adapt the mRNA vaccine within six weeks and ship initial batches within 100 days in the event of an escape variant,” the company said in a statement.

The Guardian


This timeline did not include preclinical and/or clinical trials that would be required for approval.

* This post was edited 11/28/21 04:35am by BCSnob *

BCSnob

Middletown, MD

Senior Member

Joined: 02/23/2002

View Profile



Posted: 11/28/21 04:44am Link  |  Quote  |  Print  |  Notify Moderator

This article discusses the likely processes to be followed for approval of a “tweaked” vaccine to target a new variant.

COVID vaccine makers brace for a variant worse than Delta
Nature 20 Oct 2021

One possible way to access a vaccine against a new variant is to volunteer for a clinical trial for those vaccines.

* This post was edited 11/28/21 05:33am by BCSnob *

silversand

Montreal

Senior Member

Joined: 09/12/2004

View Profile



Posted: 11/28/21 05:52am Link  |  Quote  |  Print  |  Notify Moderator

BC Snob wrote:

This timeline did not include preclinical and/or clinical trials that would be required for approval.


Thanks. Check.

Deb and Ed M

SW MI & Space Coast, FL USA

Senior Member

Joined: 06/07/2004

View Profile



Posted: 11/30/21 06:46am Link  |  Quote  |  Print  |  Notify Moderator

MSNBC is saying this morning that researchers suspect that the current monoclonal treatments aren't going to work with the Omicron variant?

BCSnob

Middletown, MD

Senior Member

Joined: 02/23/2002

View Profile



Posted: 11/30/21 07:49am Link  |  Quote  |  Print  |  Notify Moderator

Everyone take a deep breath..

The media is writing stories without there being any new information; they are releasing new stories to create more hype.

Here are a few key quotes from the article in Nature I linked earlier.
Quote:

Many of the changes have been found in variants such as Delta and Alpha, and are linked to heightened infectivity and the ability to evade infection-blocking antibodies.

Omicron has similar mutations as delta and alpha which made them more infectious than the Wuhan strain.

Quote:

The variant harbours a high number of mutations in regions of the spike protein that antibodies recognize, potentially dampening their potency.

This is why researchers are concerned about effectiveness of therapies, natural immunity, and vaccine effectiveness. But keep in mind, higher amounts of antibodies can, in some cases, overcome reduced potency. We are currently dealing with reduced antibody potency with alpha and delta.

Vaccine manufactures and other researchers have stated it will take 2-6 weeks to collect and analyze the data on how well current therapies, natural immunity, and vaccine effectiveness deal with omicron. Until this info is released, the media will continue to hype this new variant by putting emphasis on different parts of the same limited information.

* This post was edited 11/30/21 08:11am by BCSnob *

Deb and Ed M

SW MI & Space Coast, FL USA

Senior Member

Joined: 06/07/2004

View Profile



Posted: 11/30/21 02:51pm Link  |  Quote  |  Print  |  Notify Moderator

Thank you for being the voice of reasonableness, Mark. My husband likes to watch the financial channels and that's all they are talking about

BCSnob

Middletown, MD

Senior Member

Joined: 02/23/2002

View Profile



Posted: 12/02/21 10:20am Link  |  Quote  |  Print  |  Notify Moderator

In this study, the researchers examined the data from 44,546 Healthcare Workers in the UK between 18 June 2020 and 23 April 2021 who are regularly tested (PCR tested every 14-16 days). Within the study group during this time frame there were infected, infected and then vaccinated, uninfected and vaccinated people; vaccination rate at the end of the study was 97%. Vaccination was with 2 doses of Pfizer (short or long interval between doses) or 2 doses of AstraZeneca.

Pfizer vaccine effectiveness decreased after 6 months (81% to 46% long interval, 86% to 61% short interval); due to the smaller number of people vaccinated with the short interval, the confidence intervals for both intervals were overlapping. The interval between doses had no impact on vaccine effectiveness. The waning vaccine effectiveness corresponded with the increasing prevalence of delta.

AstraZeneca vaccine effectiveness was 50% and did not decrease over the study time; the confidence in this number was not high due to the low number of AstraZeneca vaccinated people in this study.

Previous infection yielded a 90% effectiveness against re-infection with no changes up to 15months; however, these data come from a time prior to delta.

Previous infection plus vaccination yielded the best protection.

Effectiveness and durability of protection against future SARS-CoV-2 infection conferred by COVID-19 vaccination and previous infection; findings from the UK SIREN prospective cohort study of healthcare workers March 2020 to September 2021
MedRxiv Preprint 1 Dec 2021

Quote:

Conclusions

Two doses of BNT162b2 vaccination, given with a short or long-interval, induce high protection to SARS-CoV-2 infection (asymptomatic and symptomatic) in the short-term, but this protection wanes after six months, during a period where Delta predominates. Protection provided from two doses of ChAdOX1 is considerably lower overall. The highest and most durable protection is observed in those with hybrid immunity who received one or two doses of vaccine after a primary infection....


These data suggest that 2 doses of Pfizer provided similar immunity as a previous infection (infection from an earlier variant than delta); once delta became the dominate variant vaccine induced immunity waned while there was no data for natural immunity from a previous variant against delta.

Vaccine boosting of a previous infection (from an earlier variant) provided the best immunity as delta became dominate.

* This post was edited 12/02/21 10:28am by BCSnob *

BCSnob

Middletown, MD

Senior Member

Joined: 02/23/2002

View Profile



Posted: 12/03/21 10:19am Link  |  Quote  |  Print  |  Notify Moderator

Don’t tell anyone, but mask mandates are effective.

Missouri Withheld Data Showing Effectiveness of Mask Mandates

Reply to Topic  |  Subscribe  |  Print Page  |  Post New Topic  | 
Page of 163  
Prev  |  Next

Open Roads Forum  >  Around the Campfire  >  General Topics

 > 2019–2022 CORONAVIRUS PANDEMIC POSTINGS
Search:   Advanced Search

Search only in Around the Campfire


New posts No new posts
Closed, new posts Closed, no new posts
Moved, new posts Moved, no new posts

Adjust text size:




© 2022 CWI, Inc. © 2022 Good Sam Enterprises, LLC. All Rights Reserved.