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Open Roads Forum  >  Around the Campfire  >  General Topics

 > 2019–2022 CORONAVIRUS PANDEMIC POSTINGS

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Deb and Ed M

SW MI & Space Coast, FL USA

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Posted: 06/08/21 08:51am Link  |  Quote  |  Print  |  Notify Moderator

One universal vaccine would be wonderful!! I'm under the impression that SARS and MERS are still around, too? Are the "seasonal coronaviruses" what we layfolks would call "colds"? (AKA the "grandchild gift")

BCSnob

Middletown, MD

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Posted: 06/08/21 09:43am Link  |  Quote  |  Print  |  Notify Moderator

WHO: MERS

I can’t find info on new cases of sars-cov-1

The seasonal coronaviruses are causes of “colds” but I don’t think they are the only causes of “colds”

* This post was edited 06/08/21 09:50am by BCSnob *

Deb and Ed M

SW MI & Space Coast, FL USA

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Posted: 06/09/21 05:03pm Link  |  Quote  |  Print  |  Notify Moderator

Thanks, Mark!

MEXICOWANDERER

las peñas, michoacan, mexico

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Posted: 06/10/21 11:22pm Link  |  Quote  |  Print  |  Notify Moderator

Questions "Breakthroughs"

How transmissible is the virus in the event of a diagnosed "positive"?

Is a breakthrough on a post viral case more serious than a vaccinated individual?

Thank you for your consideration!

BCSnob

Middletown, MD

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Posted: 06/11/21 06:05am Link  |  Quote  |  Print  |  Notify Moderator

This preprint posted today of a “ Multicenter observational cohort analysis Setting: Eight-hospital acute care regional health system in Michigan” addresses your second question in terms of how common and severe vaccine breakthrough case are.

Vaccination reduces need for emergency care in breakthrough COVID-19 infections: A multicenter cohort study
MedRxiv preprint doi: https://doi.org/10.1101/2021.06.09.21258617

This is part of the introduction.

Quote:

In the latest surge of COVID-19, the state of Michigan has been more severely impacted than the rest of the United States.1 In Michigan the volume of peaked to over 7,000 new daily cases between April 5th and April 12th 2021.13 According to the CDC, over a 2 week period ending April 24, 2021, 10 COVID-19 variants were detected within the region.14 The most common, B.1.1.7 variant, has been identified as the cause of over 50% of new COVID-19 diagnosis in the State of Michigan.14 While the B.1.1.7 variant has shown to be associated with increased transmissibility, to date there has been no evidence to suggest or negate the impact on vaccine efficacy. However, in-vitro studies have noted a loss in neutralizing activity by vaccine-induced antibodies when the E484K mutation was introduced to the B.1.1.7 variant.15


Quote:

Results: 10,880 (91.9%) UV, 825 (7%) PV, and 129 (1.1%) FV were included. Average age was 53.0 +/- 18.2 and 52.8% were female. Accounting for the COVID-19 vaccination population groups in Michigan, the ED encounters/hospitalizations rate relevant to COVID-19 infection was 96% lower in FV versus UV (eB:0.04,95% CI 0.03 to 0.06, p <0.001) in negative binomial regression. COVID-19 EC visits rate peaked at 22.61, 12.88, and 1.29 visits per 100000 for the UV, PV, and FV groups, respectively. In the propensity-score matching weights analysis, FV had a lower risk of composite disease compared to UV but statistically insignificant (HR 0.84 95% CI 0.52 to 1.38).

UV = unvaccinated
PV = partially vaccinated
FV = fully vaccinated

Quote:

Conclusions: The need for emergency care and/or hospitalization due to breakthrough COVID-19 is an exceedingly rare event in fully vaccinated patients. As vaccination has increased within our region, emergency visits amongst fully vaccinated individuals have remained low and occur much less frequently when compared to unvaccinated individuals. In cases of breakthrough COVID-19, if hospital-based treatment is required, elderly patients with significant comorbidities remain at high risk for severe outcomes regardless of vaccination status.


The bolded statement in the conclusions may be of interest to you.

* This post was edited 06/11/21 06:20am by BCSnob *

BCSnob

Middletown, MD

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Posted: 06/15/21 09:46am Link  |  Quote  |  Print  |  Notify Moderator

During the phase 3 clinical trial of novavax’s covid-19 vaccine, the safety and immunogenicity of combining the covid-19 with the seasonal flu vaccines was tested. The preprint of this portion of the clinical trial was just posted.

Safety, Immunogenicity, and Efficacy of a COVID-19 Vaccine (NVX-CoV2373) Co-administered With Seasonal Influenza Vaccines
MedXiv preprint doi: https://doi.org/10.1101/2021.06.09.21258556

Quote:

The first ~400 participants meeting main study entry criteria and with no contraindications to influenza vaccination were invited to join the sub-study. After randomization in a 1:1 ratio to receive NVX-CoV2373 (n=217) or placebo (n=214), sub-study participants received an age-appropriate, licensed, open-label influenza vaccine with dose 1 of NVX-CoV2373.


Novavax covid-19 vaccine with flu vaccine or with placebo.

Quote:


Sub-study participants were younger, more racially diverse, and had fewer comorbid conditions than main study participants. Reactogenicity events more common in the co-administration group included tenderness (70.1% vs 57.6%) or pain (39.7% vs 29.3%) at injection site, fatigue (27.7% vs 19.4%), and muscle pain (28.3% vs 21.4%). Rates of unsolicited AEs, MAAEs, and SAEs were low and balanced between the two groups. Co-administration resulted in no change to influenza vaccine immune response, while a reduction in antibody responses to the NVX-CoV2373 vaccine was noted. Vaccine efficacy in the sub-study was 87.5% (95% CI: -0.2, 98.4) while efficacy in the main study was 89.8% (95% CI: 79.7, 95.5).


Mild reactions were more common in the group getting 2 vaccines than those getting the Covid-19 vaccine & a placebo. There was no difference in more serious reactions between the groups. The 2 vaccine group had slightly lower covid-19 efficacy (confirmed symptomatic mild or severe sars-cov-2 infection) than the covid vaccine & placebo group.

BCSnob

Middletown, MD

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Joined: 02/23/2002

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Posted: 06/15/21 09:55am Link  |  Quote  |  Print  |  Notify Moderator

Early evidence for the safety of certain COVID-19 vaccines using empirical Bayesian modeling from VAERS
MedRxiv preprint doi: https://doi.org/10.1101/2021.06.10.21258589

Quote:

Abstract

The advent of vaccines against SARS-CoV-2 ushered in an unprecedented global response to COVID-19, with the largest and most ambitious mass vaccination campaign in human history. The scale of this effort means that safety signals suggesting adverse effects may only be detectable using passive reporting. This paper examines reports to the CDC/FDA’s VAERS system in the first six months of 2021, using an empirical Bayesian model with a gamma Poisson shrinker to identify potential safety signals from COVID-19 vaccines currently on the U.S. market. Based on this preliminary data, it is concluded that the COVID-19 vaccine’s safety significantly exceeds that of previously marketed vaccines, and other than a known risk of thrombotic events, no safety signals of concern emerge.


A statistical analysis was performed using the VAERS system to assess the safety of covid-19 vaccines to other vaccines.

wa8yxm

Davison Michigan (East of Flint)

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Posted: 06/24/21 05:05am Link  |  Quote  |  Print  |  Notify Moderator

Some good news where I'm at.
Not long ago the 2 week average infection rate was 96/100,000 or 0.96% per day
Last two weeks well we kept the 9, but moved it a bit 0.9 per 100,000 or 0.009% We are almost to the ideal rate of 0.000000000 per total population of county.


Home was where I park it. but alas the.
2005 Damon Intruder 377 Alas declared a total loss
after a semi "nicked" it. Still have the radios
Kenwood TS-2000, ICOM ID-5100, ID-51A+2, ID-880 REF030C most times


Deb and Ed M

SW MI & Space Coast, FL USA

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Posted: 06/30/21 01:45pm Link  |  Quote  |  Print  |  Notify Moderator

Mark - didn't I read a while back that about 5% of all positive Covid tests get checked for variants? (Because it's time consuming and expensive) The Delta Variant is being found in Michigan and I see the new case rate starting to creep back up. I suspect the numbers reported are merely the tip of the iceberg.

Is there any research showing how the antibodies produced by having Covid, (presuming the UK/"Alpha" Variant) protect against the Delta variant? Or is it too early in that fight? I also have to admit being concerned about this article's statistics saying that 2/3 of the people who have tested positive for the Delta Variant in the UK were unvaccinated - I'm reading "1/3 of the people who tested positive WERE vaccinated"
BBC Health News

dturm

Lake County, IN

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Posted: 06/30/21 04:09pm Link  |  Quote  |  Print  |  Notify Moderator

While some individuals previously vaccinated have turned up positive to the Delta variant, it's my understanding that most of those do NOT usually get serious disease. In areas where the Delta variant is prevalent, a huge majority of those hospitalized are unvaccinated.


Doug & Sandy
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