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Open Roads Forum  >  Around the Campfire  >  General Topics

 > 2019–2022 CORONAVIRUS PANDEMIC POSTINGS

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Deb and Ed M

SW MI & Space Coast, FL USA

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Posted: 08/06/21 08:12am Link  |  Quote  |  Print  |  Notify Moderator

BCSnob wrote:

Good question

First the FDA must finalize their requirements for testing boosters; the linked article has the FDA’s “current thinking” on what they might require. I suspect that with delta inducing breakthrough infections that are just as infectious as infections in unvaccinated people the FDA & CDC will shift their stance on the need for boosters.


Thanks for the link to the Pfizer booster info - that's good news!

dturm

Lake County, IN

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Posted: 08/06/21 10:21am Link  |  Quote  |  Print  |  Notify Moderator

The other issue is a public health philosophical issue. Will more people in this country be protected more rapidly from these variants and future variants if the vaccine supply is distributed around the world? The WHO thinks so, but some public health officials point to the fact that the US is a major hot spot right now and we need to shut this thing down now. While ignoring the rest of the world will come back to bite us, we need to concentrate on the US right now IMO.

Pfizer and Moderna are reworking their vaccine to include the Delta spike protein to increase efficacy of their vaccines. Testing is supposed to start soon.

Regarding breakthroughs, even if it happens the vaccine is still almost 100% effective in prevent serious illness and hospitalization. We hear about the breakthroughs, but in reality they are very rare. Hospitalizations and deaths right now are close to 100% non-vaccinated individuals.

We need to get more people vaccinated so people like Steveh27 can breathe more easily. There are a lot of people in his situation.


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JaxDad

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Posted: 08/06/21 11:40am Link  |  Quote  |  Print  |  Notify Moderator

dturm wrote:

We need to get more people vaccinated so people like Steveh27 can breathe more easily. There are a lot of people in his situation.


That is likely to be the single biggest nut to crack.

Have a read over this article.

MEXICOWANDERER

las peñas, michoacan, mexico

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Posted: 08/06/21 12:26pm Link  |  Quote  |  Print  |  Notify Moderator

Are there any USA studies underway for heterologous prime and boost, for COVID-19? This would be one way to arrive at a booster for FDA permitted vaccinated.

A solo vaccination with SINOVAC is not going to cut it with me. Mexico foolishly imported tens of millions of doses of the Chinese vaccine, and now the outbreak of non-mitigated illnesses in China have people worried.

BCSnob

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Posted: 08/06/21 01:20pm Link  |  Quote  |  Print  |  Notify Moderator

MEXICOWANDERER wrote:

Are there any USA studies underway for heterologous prime and boost, for COVID-19? This would be one way to arrive at a booster for FDA permitted vaccinated.

Not that I'm aware of.

I believe (but am not certain) when the medical industry speaks of heterologous prime and boost they are talking about a vaccination protocol of 1st shot from manufacture A followed by 2nd shot from manufacturer B. What you are proposing is 1st & 2nd shot (if that vaccine requires 2 shots) from manufacturer A followed by 3rd shot from manufacturer B. I believe the heterologous prime and boost is being studied as a means to deal with supply issues of vaccines.

All of the vaccines with EUAs are based upon the Wuhan variant sequence; boosting with a different EUA vaccine may not increase cross reactivity against the newer viral variants.

The data from the two Pfizer vaccine studies (linked in previous posts) would suggest that having higher antibody titers would be sufficient (with the current variants) to restore Pfizer's vaccine efficacy. A boost from the same vaccine should be sufficient to increase antibody titers.

BCSnob

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Posted: 08/06/21 02:22pm Link  |  Quote  |  Print  |  Notify Moderator

This study (Preprint Vaccination with B.1.1.7, B.1.351 and P.........om challenge 2 with wild type SARS-CoV-2) touches on some of the issues of developing a booster. Here the researchers prepared vaccines analogous to the type (vaccine platform) in clinical studies from Novavax using the genetic sequences from several variants and then vaccinated mice.

Quote:

we vaccinated mice with recombinant spike proteins from the wild type Wuhan-1 strain ('wild type', strain used to make all vaccines with EUAs), B.1.1.7 (alpha), B.1.351 (beta) and P.1 (gamma) and assessed the resulting cross-neutralization in the sera. Furthermore, we challenged the animals with wild type strain, SARS-CoV-2/human/USA/USA-WA1/2020 (WA1) of SARS-CoV-2 to determine if variant vaccine antigens would still protect from the prototypic virus. Adjuvanted, recombinant spike proteins were chosen as antigen since they reflect vaccines currently in clinical development by Novavax, Sanofi Pasteur and other vaccine manufacturers.


The researchers then measured the cross-neutralizing antibodies produced by each vaccine against these SARS-CoV-2 variants. Each vaccine was good at neutralizing the variant upon which the vaccine was based; neutralization was typically lower against the other variants. There was one exception; the vaccine based upon SARS-CoV-2 Gamma provided equivalent neutralization against the other viral variants.

The researchers were not able to include the SARS-Cov-2 variants Delta, Kappa, and Lambda.

MEXICOWANDERER

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Posted: 08/06/21 05:58pm Link  |  Quote  |  Print  |  Notify Moderator

I can only hope new mRNA composition is arrived at before variants arrive at the Omega title. The arrival of a mutagen with Delta significance so early in the progression is troubling.

Deb and Ed M

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Posted: 08/07/21 07:56am Link  |  Quote  |  Print  |  Notify Moderator

JaxDad wrote:


Have a read over this article.


Well THAT was terrifying. I'm afraid the people who NEED to read that either won't understand it - or simply don't care. I have enjoyed this summer of "back to what used-to-be" (no masks, dining indoors at restaurants, etc) but am slowly wrapping my head around a forever life-wearing-masks-in-public and "yes I have to cook dinner" :-(

MEXICOWANDERER

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Posted: 08/07/21 08:20pm Link  |  Quote  |  Print  |  Notify Moderator

I just tried to read through that article. My conclusion? We are so fortunate to have Johns Hopkins virology specialists sorting through conflicting information and distilling it into verified facts conclusions and tips. If you want to read runaway opinions assertions and conjecture I highly recommend studying live reporting the 1918 H1N1 pandemic in which dozens of "consultants" MDs expressed their opinions about the Pandemic.

This is a small segment of my college medical studies in virology. Reality versus newspaper columns. Frankly many "documented" news blurbs were so far off the rails that today they are absurd.

Verified peer reviewed information as issued by Johns Hopkins never once (in my experience) stated there would be "x" number of mutations. And I have not run across a single report by JH that I could effectively argue with. And by nature I am a pessimist.

Pfizer, Moderna, and Oxford University are leading the virology world in determining what kind of changes need to be made in today's vaccines to minimize impact of a future COVID19 variant.

Instead of panicking I intend to follow their advice to the letter (which has worked so far), even though it may contain recommendations that are inconvenient like masking, distancing, and avoiding certain activities.

But I shall offer this one opinion about what I see and what I have studied to excess:

The Covid19 issues of today are like A Walk In The Park compared to the pandemic of 1918. This is due to education and medicine and efforts by entities like Johns Hopkins that insist on proof and ignore newspaper articles.

BCSnob

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Posted: 08/09/21 07:09am Link  |  Quote  |  Print  |  Notify Moderator

Phase 1/2 clinical trial of CoronaVac booster.

A booster dose is immunogenic and will be needed for older adults who have completed two doses vaccination with CoronaVac: a randomised, double-blind, placebo-controlled, phase 1/2 clinical trial
Preprint

Antibody titers decreased below a threshold value (not sure how this value was selected) 6 months after 2nd dose of the initial vaccination. A booster at 8 months yielded higher antibody titers than measured after the 2nd shot of the initial vaccination.

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